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  • Guess this pathology?

    A 26 y/o medical student who took primaquine for malaria prophylaxis for a mission trip to Nigeria presents with malaise, fatigue and weakness. A peripheral smear shows the following.What is this pathology?
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  • #2
    Answer:A 26 y/o medical student who took primaquine for malaria prophylaxis for a mission trip to Nigeria presents with malaise, fatigue and weakness. A peripheral smear shows bite cells.
    Oxidant induce hemolysis can occur in G6PD deficiency , caused by drugs(most common dapsone), oxidant particles, or endogenous(Wilson's disease).
    Men of African or African American ancestry who are homozygous, can have normal levels of G6PD after hemolysis, because the reticulocyte count is high.
    Certain groups that are also carriers(Mediterranean variant), can have normal G^PD after hemolysis, because the bad cells have preferentially being lysed. This is why the peripheral smear is important for diagnosis.

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